Organic chemistry

  

Anion-binding mechanisms in H-bonding catalysis

 

  • Development of new, catalytic and asymmetric transformations of N-Acyl dehydroalanine: a versatile molecular scaffold in medicinal chemistry synthesis

 

 
  • Indole-based natural product synthesis.

Selected Publications:

Bartoccini F., Mari M., Retini M., Bartolucci S., Piersanti G. (2018) Organocatalytic Aza-Friedel–Crafts/Lactonization Domino Reaction of Naphthols and Phenols with 2-Acetamidoacrylate to Naphtho- and Benzofuranones Bearing a Quaternary Center at the C3 Positio. Journal of Organic Chemistry, 2018, 83, 19, 12275-12283

Di Gregorio G., Mari M., Bartoccini F., Piersanti G. (2017) Iron-Catalyzed Direct C3-Benzylation of Indoles with Benzyl Alcohols through Borrowing Hydrogen. Journal of Organic Chemistry, 82, 16, 8769-877

Bartoccini F., Cannas DM., Fini F., Piersanti G. ( 2016) Palladium(II)-Catalyzed Cross-Dehydrogenative Coupling (CDC) of N-Phthaloyl Dehydroalanine Esters with Simple Arenes: Stereoselective Synthesis of Z-Dehydrophenylalanine Derivative. Org. Lett., 18 (11), 2762-2765.

S Bartolucci, M Mari, A Bedini, G Piersanti, G Spadoni (2015) Iridium-Catalyzed Direct Synthesis of Tryptamine Derivatives from Indoles: Exploiting N-Protected beta-Amino Alcohols as Alkylating Agents. JOURNAL OF ORGANIC CHEMISTRY 80 (6), 3217–3222

BARTOCCINI F, CASOLI M, MARI M, PIERSANTI G (2014) Synthesis of (+/-)-cis-Clavicipitic Acid by a Rh (I)-Catalyzed Intramolecular Imine Hydroarylation Reaction. JOURNAL OF ORGANIC CHEMISTRY, 79 (7), 3255–3259

MARI M, BARTOCCINI F, PIERSANTI G (2013) Synthesis of (−)-Epi-Indolactam V by an Intramolecular Buchwald–Hartwig C–N Coupling Cyclization Reaction. JOURNAL OF ORGANIC CHEMISTRY, 78 (15), 7727-7734

S. BARTOLUCCI, F. BARTOCCINI, M. RIGHI, G. PIERSANTI (2012) Direct, Regioselective, and Chemoselective Preparation of Novel Boronated Tryptophans by Friedel–Crafts Alkylation. ORGANIC LETTERS, 14 (2), 600–603.

RIGHI M, BARTOCCINI F, LUCARINI S, PIERSANTI G (2011) Organocatalytic synthesis of α- quaternary amino acid derivatives via aza-Friedel–Crafts alkylation of indoles with simple α- amidoacrylates TETRAHEDRON, Vol. 67, Issue 41, 7923-7928.

LUCARINI S, BARTOCCINI F, BATTISTONI F, DIAMANTINI G, PIERSANTI G., RIGHI M, SPADONI G (2010). A Novel One-Pot Approach Of Hexahydropyrrolo[2,3-b]Indole Nucleus By A Cascade Addition/Cyclization Strategy: Synthesis Of (±)-Esermethole. ORGANIC LETTERS, vol. 12; p. 3844-3847.

PIERSANTI G., REMI F, FUSI V, FORMICA M, GIORGI L, ZAPPIA G (2009). Direct Preparation of Unsymmetrical Difunctionalized Cyclen Derivatives by an Ugi Multicomponent Reaction. ORGANIC LETTERS, vol. 11; p. 417-420.

ANGELINI E, BALSAMINI C, BARTOCCINI F, LUCARINI S, PIERSANTI G. (2008). Switchable reactivity of acylated alpha, beta-dehydroamino ester in the Friedel-Crafts alkylation of indoles by changing the Lewis acid. JOURNAL OF ORGANIC CHEMISTRY, vol. 73; p. 5654-5657.

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